BPC-157 (5mg)

BPC-157 (5mg)

$49.99
$49.99
SAVE Sold out
BPC-157 (5mg)

BPC-157 (5mg)

$49.99
$49.99
SAVE Sold out

BPC-157 (Body Protection Compound 157) is a synthetic pentadecapeptide consisting of 15 amino acids, originally identified as a fragment of a naturally occurring protein in human gastric juice. With a molecular weight of 1419.5 g/mol and verified purity of ≥99% (HPLC), BPC-157 is supplied in lyophilized powder form for laboratory research applications. Its stability and consistency make it a valuable material for scientific studies exploring peptide activity in controlled settings.

Disclaimer: This product is intended strictly for research use only and is not for human consumption, therapeutic, or diagnostic purposes.

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What is BPC-157?

BPC-157 is a synthetic 15-amino acid peptide sequence originally identified in human gastric juice. This research compound has been extensively studied in laboratory settings for its interactions with tissue repair pathways, angiogenesis processes, and cellular protective mechanisms. The peptide represents a partial sequence of the naturally occurring body protection compound and has become a subject of significant scientific interest. Research investigations have examined its molecular interactions with various biological systems, including wound healing cascades, vascular development processes, and inflammatory response pathways.

Chemical Structure of BPC‑157

BPC-157 is a pentadecapeptide with the amino acid sequence: Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val. The compound has a molecular formula of C₆₂H₉₈N₁₆O₂₂ and molecular weight of 1419.556 g/mol (PubChem CID: 108101). This synthetic peptide demonstrates notable stability under standard laboratory conditions and maintains structural integrity across various pH environments, making it suitable for diverse experimental protocols. The compound is also referenced in scientific literature as Body Protection Compound-157, reflecting its original identification and isolation from human gastric secretions.

Research and Clinical Studies on BPC-157

1. Cellular Repair & Tissue Studies: Laboratory investigations have examined BPC-157's interactions with fibroblast proliferation, collagen synthesis, and angiogenic signaling in tissue culture models. Research has documented the peptide's influence on extracellular matrix formation, cellular migration, and key proteins including focal adhesion kinase (FAK) and paxillin phosphorylation pathways.

2. Gastrointestinal Research Models: Scientific studies have explored BPC-157's molecular mechanisms in gastric protection models, examining interactions with mucosal barrier systems and epithelial cell signaling. Research has documented the peptide's stability across pH environments and its role in villus-crypt architecture studies under experimental conditions.

3. Vascular Biology & Angiogenesis Research: Experimental protocols have investigated BPC-157's influence on VEGF expression, endothelial cell migration, and nitric oxide signaling. Studies have examined interactions with human umbilical vein endothelial cells (HUVECs) and documented influence on extracellular signal-regulated kinases (ERK1/2) in angiogenic pathway studies.

4. Neurological & Organ Protection Research: Preclinical studies have examined BPC-157's interactions with neural protection pathways and neurotransmitter system modulation. Research has explored its influence on dopaminergic signaling and documented the peptide's role in traumatic brain injury models and brain edema reduction mechanisms.

5. Inflammation & Oxidative Stress Research: Laboratory analyses have documented BPC-157's interactions with inflammatory mediator pathways and oxidative stress marker modulation. Studies have investigated its influence on prostaglandin systems, nitric oxide pathway regulation, and reactive oxygen species neutralization mechanisms.

6. Safety & Toxicological Research: Toxicological studies have evaluated BPC-157's safety profile with documentation of low cytotoxicity in laboratory conditions. Research has examined biocompatibility across various administration routes and established safety parameters for research applications in experimental protocols.

Citations

1. Chang, C.-H., Tsai, W.-C., Lin, M.-S., Hsu, Y.-H., and Pang, J.-H. S. "The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration." Journal of Applied Physiology, vol. 110, no. 3, pp. 774–780, 2010.

2. Seiwerth, S. et al. "BPC 157 and Standard Angiogenic Growth Factors. Gastrointestinal Tract Healing, Lessons from Tendon, Ligament, Muscle and Bone Healing." Current Pharmaceutical Design, vol. 24, no. 18, pp. 1972–1989, 2018.

3. Huang, T., Zhang, K., Sun, L., Xue, X., Zhang, C., Shu, Z., Mu, N., Gu, J., Zhang, W., Wang, Y., Zhang, Y., & Zhang, W. "Body protective compound-157 enhances alkali-burn wound healing in vivo and promotes proliferation, migration, and angiogenesis in vitro." Drug Design, Development and Therapy, vol. 9, pp. 2485–2499, 2015.

4. Hsieh, M.-J. et al. "Therapeutic potential of pro-angiogenic BPC157 is associated with VEGFR2 activation and up-regulation." Journal of Molecular Medicine, vol. 95, no. 3, pp. 323–333, 2017.

5. Sikiric, P. et al. "Novel Cytoprotective Mediator, Stable Gastric Pentadecapeptide BPC 157. Vascular Recruitment and Gastrointestinal Tract Healing." Current Pharmaceutical Design, vol. 24, no. 18, pp. 1990–2001, 2018.

6. Duzel, A. et al. "Stable gastric pentadecapeptide BPC 157 in the treatment of colitis and ischemia and reperfusion in rats: New insights." World Journal of Gastroenterology, vol. 23, no. 48, pp. 8465–8488, 2017.

7. Drmic, D. et al. "Counteraction of perforated cecum lesions in rats: Effects of pentadecapeptide BPC 157, L-NAME and L-arginine." World Journal of Gastroenterology, vol. 24, no. 48, pp. 5462–5476, 2018.